Phenoxybenzamine

Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[1][2].

Product Specifications

CAS Number

[59-96-1]

UNSPSC

12352005

Hazard Statement

H302-H351

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/phenoxybenzamine.html

Solubility

10 mM in DMSO

Smiles

CC(N(CCCl)CC1=CC=CC=C1)COC2=CC=CC=C2

Molecular Formula

C18H22ClNO

Molecular Weight

303.83

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Habbe N, et al. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013 May;37 (5) :1141-6.|[2]Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37 (3) :2901-8.|[3]Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15 (1) :1402-17.