Estriol-13C3

Estriol-13C3 is the 13C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

Product Specifications

CAS Number

[1255639-56-5]

Product Name Alternative

Oestriol-13C3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/estriol-13c3.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](C[C@H]([C@@H]2O)O)([H])[C@@]3([H])[C@@](CC1)([H])C4=C[13CH]=[13C](O)[13CH]=C4CC3

Molecular Formula

C15 13C3H24O3

Molecular Weight

291.36

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Morinaga, A., et al., Effects of sex hormones on Alzheimer's disease-associated beta-amyloid oligomer formation in vitro. Exp Neurol, 2011. 228 (2) : p. 298-302.|[3]Begum, M., et al., Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice. Lab Invest, 2006. 86 (3) : p. 286-96.|[4]Hewitt, S.C. and K.S. Korach, Estrogenic activity of bisphenol A and 2,2-bis (p-hydroxyphenyl) -1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect, 2011. 119 (1) : p. 63-70.