Pyrazinamide-d3

Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

Product Specifications

CAS Number

[1432059-16-9]

Product Name Alternative

Pyrazinecarboxamide-d3; Pyrazinoic acid amide-d3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Antibiotic; Autophagy; Bacterial; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

99.84

Solubility

10 mM in DMSO

Smiles

NC(C1=NC([2H])=C([2H])N=C1[2H])=O

Molecular Formula

C5H2D3N3O

Molecular Weight

126.13

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181 (7) :2044-9.|[3]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2 (4) :MGM2-0023-2013.