Estrone-d2

Estrone-d2 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

Product Specifications

CAS Number

[350820-16-5]

Product Name Alternative

E1-d2; Oestrone-d2

UNSPSC

12352005

Hazard Statement

H351, H360, H362

Target

Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Cancer

Purity

99.78

Solubility

10 mM in DMSO|DMSO : ≥ 20mg/mL

Smiles

O=C1CC[C@]2([C@@]3(CCC4=C(C(O)=C(C=C4[C@]3(CC[C@@]21C)[H])[2H])[2H])[H])[H]

Molecular Formula

C18H20D2O2

Molecular Weight

272.38

Precautions

H351, H360, H362

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45 (11) :3341-3350.|[3]de Padua Mansur A, et al. Long-term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease. ScientificWorldJournal. 2012;2012:363595.