Allopurinol-d2

Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM) . Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

Product Specifications

CAS Number

[916979-34-5]

UNSPSC

12352005

Hazard Statement

H301, H317

Target

Isotope-Labeled Compounds; Xanthine Oxidase

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Purity

99.36

Solubility

10 mM in DMSO|H2O : 1mg/mL (ultrasonic; adjust pH to 11 with NaOH)

Smiles

O=C1C2=C(NN=C2[2H])NC([2H])=N1

Molecular Formula

C5H2D2N4O

Molecular Weight

138.12

Precautions

H301, H317

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58 (1) :87-114.|[3]Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5 (5) :469-472.