Prostaglandin E1 (Standard)

Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

Product Specifications

CAS Number

[745-65-3]

Product Name Alternative

Alprostadil (Standard) ; PGE1 (Standard)

UNSPSC

12352211

Hazard Statement

H301

Target

Endogenous Metabolite; Prostaglandin Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Endocrinology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/prostaglandin-e1-standard.html

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O

Molecular Formula

C20H34O5

Molecular Weight

354.48

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122 (2) :217-24.|[2]Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138 (2) :377-85.|[3]Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction--a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.