Paclitaxel-d5

Paclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

Product Specifications

CAS Number

[1129540-33-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Isotope-Labeled Compounds; Microtubule/Tubulin

Type

Isotope-Labeled Compounds

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.9

Solubility

10 mM in DMSO|DMF : ≥ 5mg/mL|DMSO : ≥ 5mg/mL|Ethanol : ≥ 1.5mg/mL

Smiles

O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N[C@@H](C2=CC=CC=C2)[C@H](C(O[C@@H]3C(C)=C([C@@H](OC(C)=O)C([C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@@H]4O)([H])[C@@H]6OC(C7=CC=CC=C7)=O)=O)C(C)(C)[C@@]6(O)C3)=O)O

Molecular Formula

C47H46D5NO14

Molecular Weight

858.94

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28 (6) :2163-9.|[2]Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24 (1) :27-36.