Diphenidol

Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea[1][2][3][4][5].

Product Specifications

CAS Number

[972-02-1]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

MAChR; Sodium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/diphenidol.html

Solubility

10 mM in DMSO

Smiles

OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3

Molecular Formula

C21H27NO

Molecular Weight

309.45

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64 (3) :739-44.|[2]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58 (7) :1147-52.|[3]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58 (7) :1147-52.|[4]Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.|[5]Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17 (9) :589-90.