Tiludronate

Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

Product Specifications

CAS Number

[89987-06-4]

Product Name Alternative

Tiludronic acid

UNSPSC

12352005

Hazard Statement

H314

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tiludronate.html

Solubility

10 mM in DMSO

Smiles

O=P(O)(O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1

Molecular Formula

C7H9ClO6P2S

Molecular Weight

318.61

Precautions

P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

References & Citations

[1]Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989;2 (8678-8679) :1469-1471.|[2]Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018;89 (1) :105-116.|[3]Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17 (5 Suppl) :473S-477S.|[4]David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. J Bone Miner Res. 1996;11 (10) :1498-1507.