D-Thyroxine (sodium)

D-thyroxine (D-T4) sodium is an orally active thyroid hormone that inhibits the secretion of TSH. D-thyroxine sodium can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-thyroxine sodium can be used for the study of hypercholesterolemia[1][2][3].

Product Specifications

CAS Number

[137-53-1]

Product Name Alternative

D-T4 (sodium)

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-thyroxine-sodium.html

Solubility

10 mM in DMSO

Smiles

N[C@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(O)C(I)=C2)C(O[Na])=O

Molecular Formula

C15H10I4NNaO4

Molecular Weight

798.85

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]John J. Schrogie M.D., et al. II. The effect of D-thyroxine, clofibrate, and norethandrolone. Clinical Pharmacology and Therapeutics, Volume8, Issue1part1 January 1967 Pages 70-77|[2]Raluca-IoanaStefan, et al. Simultaneous determination of l-thyroxine (l-T4), d-thyroxine (d-T4), and l-triiodothyronine (l-T3) using a sensors/sequential injection analysis system.|[3]TUCKER RG. The biologic effects of D-thyroxine. A review. Angiology. 1962 Feb;13:85-8.