Sapropterin

Sapropterin ((6R) -BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) [1].

Product Specifications

CAS Number

[62989-33-7]

Product Name Alternative

(6R) -BH4; (6R) -Tetrahydro-L-biopterin

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Sapropterin.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C

Molecular Formula

C9H15N5O3

Molecular Weight

241.25

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69 (4) :461-76. |[2]Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18 (3) :1862-1879.