Trandolaprilate (hydrate)

Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].

Product Specifications

CAS Number

[951393-55-8]

Product Name Alternative

Trandolaprilat (hydrate) ; RU 44403 (hydrate)

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trandolaprilate-hydrate.html

Purity

97.30

Solubility

DMSO : 4.3 mg/mL (ultrasonic; warming)

Smiles

O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O.O

Molecular Formula

C22H32N2O6

Molecular Weight

420.50

References & Citations

[1]Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517. |[2]Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206 (2) :367-72.