Trandolaprilate

Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].

Product Specifications

CAS Number

[87679-71-8]

Product Name Alternative

Trandolaprilat; RU 44403

UNSPSC

12352005

Hazard Statement

H360

Target

Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trandolaprilate.html

Purity

99.42

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 13.33 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O

Molecular Formula

C22H30N2O5

Molecular Weight

402.48

Precautions

H360

References & Citations

[1]Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206 (2) :367-72. |[2]Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517.