(E/Z)-THZ1 (dihydrochloride)
Product Specifications
UNSPSC Description
(E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect[1][2].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-thz1-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5.[H]Cl.[H]Cl
Molecular Weight
638.97
References & Citations
[1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014;511(7511):616-620.|[2]Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015;59(4):576-587.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-80013B/E-Z-THZ1-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-80013B/
Clinical Information
No Development Reported
CAS Number
2095433-94-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6457903-01 0.1 mL
OR2T7 (Olfactory Receptor 2T7, OST723, Olfactory Receptor OR1-44, OR2T7, OR2T7P) (FITC)
Ask
View Details