Monomethyl auristatin E intermediate-9

Monomethyl auristatin E intermediate-9 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162) . Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[120205-58-5]

UNSPSC

12352005

Hazard Statement

H301

Target

Drug Intermediate; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-9.html

Purity

98.75

Solubility

10 mM in DMSO

Smiles

CC[C@H](C)[C@@H]([C@@H](CC(OC(C)(C)C)=O)OC)N(C(OCC1=CC=CC=C1)=O)C

Molecular Formula

C22H35NO5

Molecular Weight

393.52

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.