Acetaminophen-d3

Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

Product Specifications

CAS Number

[60902-28-5]

Product Name Alternative

Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H401

Target

COX; Endogenous Metabolite; Histone Acetyltransferase

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 250mg/mL (ultrasonic) |H2O : 10mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(O)C=C1)C([2H])([2H])[2H]

Molecular Formula

C8H6D3NO2

Molecular Weight

154.18

Precautions

H302, H315, H319, H335, H401

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.