CX-5011

CX-5011 is a CK2 inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death[1][2].

Product Specifications

CAS Number

[1333382-30-1]

UNSPSC

12352005

Target

Apoptosis; Casein Kinase; Ras

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cx-5011.html

Purity

99.48

Solubility

DMSO : 3.64 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C2C3=CN=CN=C3C(NC4=CC=CC(C#C)=C4)=NC2=C1)O[Na]

Molecular Formula

C20H11N4NaO2

Molecular Weight

362.32

References & Citations

[1]D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867 (11) :118807.|[2]Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7 (14) :18204-18.