Taltobulin intermediate-7
Product Specifications
UNSPSC Description
Taltobulin intermediate-7 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taltobulin-intermediate-7.html
Purity
97.33
Solubility
10 mM in DMSO
Smiles
CC([C@@H](/C=C(C)/C(OCC)=O)N(C([C@@H](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C)C
Molecular Weight
412.56
References & Citations
[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-41069/Taltobulin-intermediate-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-41069/
Clinical Information
No Development Reported
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