ML243
ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP. ML243 may target the Wnt pathway at the protein level without altering RNA expression levels[1].
Product Specifications
CAS Number
[1426576-80-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml243.html
Solubility
10 mM in DMSO
Smiles
CCC1=CC=C(/C=C/C(NC2=NCCS2)=O)C=C1
Molecular Formula
C14H16N2OS
Molecular Weight
260.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Carmody L, et al. Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3. 2011 Sep 28 [updated 2013 Mar 7].
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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