Vorozole

Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3].

Product Specifications

CAS Number

[129731-10-8]

Product Name Alternative

(+) -Vorozole; R83842

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vorozole.html

Solubility

10 mM in DMSO

Smiles

CN1N=NC2=CC=C([C@H](C3=CC=C(Cl)C=C3)N4N=CN=C4)C=C21

Molecular Formula

C16H13ClN6

Molecular Weight

324.77

References & Citations

[1]Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :617-21.|[2]Wiseman LR, et al. Vorozole. Drugs Aging. 1997 Sep;11 (3) :245-50; discussion 251-2.|[3]Lubet RA, et al. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis. 1998 Aug;19 (8) :1345-51.|[4]Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :617-21.