UCB-35440
Product Specifications
UNSPSC Description
UCB-35440 is an orally active histamine H1 receptor antagonist and 5-lipoxygenase inhibitor. UCB-35440 inhibits LTB4 formation in human whole blood and reduces polymorphonuclear cell infiltration in mouse models. UCB-35440 inhibits histamine-stimulated bronchoconstriction and reduces skin inflammation in guinea pigs. UCB-35440 can be used for research on asthma and skin inflammation[1][2].
Target Antigen
Histamine Receptor; Lipoxygenase
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ucb-35440.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C1=CC(C#CCCN(C(N)=O)O)=CC=C1OCCN2CCN([C@@H](C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2
Molecular Weight
576.09
References & Citations
[1]Giannaras A, et al. The effect of a novel, dual function histamine H1 receptor antagonist/5-lipoxygenase enzyme inhibitor on in vivo dermal inflammation and extravasation. Eur J Pharmacol. 2005 Jan 4;506(3):265-71. |[2]Oliver Werz, et al. Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds. Expert Opin Ther Patents. 2005 May 10; 15(5):505-519.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19443/UCB-35440-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19443/
Clinical Information
Phase 2
CAS Number
299460-62-1
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