GYKI-47261 (dihydrochloride)
Product Specifications
UNSPSC Description
GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1[1][2].
Target Antigen
Cytochrome P450; iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gyki-47261-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1.[H]Cl.[H]Cl
Molecular Weight
395.71
References & Citations
[1]Abrahám G, et al. New non competitive AMPA antagonists. Bioorg Med Chem. 2000;8(8):2127-2143.|[2]Tamási V, et al. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug Metab Dispos. 2003;31(11):1310-1314.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19435A/GYKI-47261-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19435A/
Clinical Information
No Development Reported
CAS Number
1217049-32-5
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