Vacquinol-1

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC) cell[3].

Product Specifications

CAS Number

[5428-80-8]

Product Name Alternative

NSC13316

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

P38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vacquinol-1.html

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24

Molecular Formula

C21H21ClN2O

Molecular Weight

352.86

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18 (1) :557-563.|[2]Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8 (21) :35124-35137. |[3]Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881.|[4]Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24 (8) :910-1.|[5]Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18 (1) :557-563.