Lisinopril-d5

Lisinopril-d5 is the deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

Product Specifications

CAS Number

[1356905-39-9]

Product Name Alternative

MK-521-d5

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H361

Target

Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Purity

96.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CC[C@@H](C(O)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O

Molecular Formula

C21H26D5N3O5

Molecular Weight

410.52

Precautions

H315, H319, H335, H361

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581 (18) : p. 3449-54.|[3]Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41 (3) : p. 207-24.