Valsartan-d3

Valsartan-d3 is the deuterium labeled Valsartan[1]. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[2].

Product Specifications

CAS Number

[1331908-02-1]

Product Name Alternative

CGP 48933-d3

UNSPSC

12352005

Hazard Statement

H360, H412

Target

Angiotensin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

94.36

Solubility

10 mM in DMSO

Smiles

CC(C)[C@@H](C(O)=O)N(C(CCCC([2H])([2H])[2H])=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2

Molecular Formula

C24H26D3N5O3

Molecular Weight

438.54

Precautions

H360, H412

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18 (6) :1071-80.|[3]Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38 (10) :2529-40.|[4]Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19 (8) :1773-82.|[5]Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24 (4) :224-9.|[6]Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.