(+) -KCC2 blocker 1
(+) -KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+) -KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].
Product Specifications
CAS Number
[1228439-71-1]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/plus-kcc2-blocker-1.html
Purity
98.68
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=CC=C1)C2(CC3=CC=C(S(=O)(C)=O)C=C3)N(C(C)=O)CCC2
Molecular Formula
C22H25NO5S
Molecular Weight
415.50
References & Citations
[1]Pégurier C, et al. Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2542-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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