Timolol

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

Product Specifications

CAS Number

[26839-75-8]

Product Name Alternative

(S) -L-714,465; MK 950 (free base)

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Cardiovascular Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/timolol.html

Solubility

10 mM in DMSO

Smiles

O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C

Molecular Formula

C13H24N4O3S

Molecular Weight

316.42

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]James Barnes; Majid Moshirfar. Timolol.|[2]E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22 (1) :152.|[3]Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 2014 Oct;46 (5) :377-87.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β adrenergic receptor

Citation 01

Patent. US20230090708A1.|Redox Biol. 2024 Dec 21:79:103481.|Adv Mater. 2025 Jan 6:e2419306.|Mater Today Bio. 2025 Apr 12:32:101752.|Protein Cell. 2019 Mar;10 (3) :178-195.