Aromatase-IN-3
Product Specifications
UNSPSC Description
Aromatase-IN-3 (compound 7d) is an aromatase inhibitor with an IC50 of 54 nM. Through suppressing the conversion of androstenedione to oestrogen caused by aromatase, Aromatase-IN-3 exerts an appreciable tumor growth inhibitory activities against breast cancer cell lines, suggesting its usage for ER+ cancer research[1].
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/aromatase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C(OCC)=O)C1=CN(CCCCCNC2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=CC=C4)\C)C=C2)C5=C1C=CC=C5
Molecular Weight
570.72
References & Citations
[1]Rani S, et al. Targeting aromatase to restrain oestrogen production and developing efficacious interventions against ER-positive cancer. Eur J Med Chem. 2023 Dec 31;265:116111.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162105/Aromatase-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162105/
Clinical Information
No Development Reported
Curated Selection
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