DTAG-13-NEG (TFA)
DTAG-13-NEG TFA is a negative control of dTAG-13 (HY-114421) . dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest[1][2].
Product Specifications
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dtag-13-neg-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(OCCCCCCNC(COC3=C(C=CC=C3)[C@@H](CCC4=CC(OC)=C(C=C4)OC)OC([C@H]5N(CCCC5)C([C@H](C6=CC(OC)=C(C(OC)=C6)OC)CC)=O)=O)=O)C=CC=C2C(N1C7C(N(C(CC7)=O)C)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C60H71F3N4O17
Molecular Weight
1177.22
References & Citations
[1]Behnam Nabet, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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