JAK1-IN-14

JAK1-IN-14 (Compound 12a) is a potent and selective JAK1 inhibitor. JAK1-IN-14 inhibits JAK1 and JAK2 with an IC50 value of 12.6 nM and 135 nM. JAK1-IN-14 suppresses hepatic fibrosis levels and can be used for the research of liver fibrosis and inflammatory diseases[1].

Product Specifications

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak1-in-14.html

Solubility

10 mM in DMSO

Smiles

CN(C1CCN(CC(N2CCC(C)CC2)=O)CC1)C3=C4C(NC=C4)=NC=N3

Molecular Formula

C20H30N6O

Molecular Weight

370.49

References & Citations

[1]Zhang J, et al. Structure-guided design of potent JAK1-selective inhibitors based on 4-amino-7H-pyrrolo[2,3-d]pyrimidine with anti-inflammatory efficacy. Arch Pharm (Weinheim) . 2024 Jan 7:e2300591.