WD6305
WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity[1]. (Pink: UZH2 (HY-115717) ; Black: Linker; Blue: VHL ligand (HY-150803) )
Product Specifications
UNSPSC
12352005
Target
Apoptosis; METTL3; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wd6305.html
Purity
98.06
Solubility
DMSO : ≥ 100 mg/mL
Smiles
Molecular Formula
C61H75F2N11O5S
Molecular Weight
1112.38
References & Citations
[1]Du W, et al. Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol. 2024 Jan 2:S2451-9456 (23) 00439-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
RSC Med Chem. 2025 Jun 19.|Cancer Res. 2025 Aug 27.
Available Sizes
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