BPP-2

BPP-2 is a GHSR ligand with an F element. Using 18F isotope labeling BPP-2, a PET probe targeting GHSR can be obtained. The binding affinity Ki of 18F-BPP-2 for GHSR is 274 nM[1].

Product Specifications

UNSPSC

12352005

Target

GHSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bpp-2.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(N)=C(C(COCC2=CC=CC=C2)=N1)C3=CC=C(C=C3)NCC4=CC=C(C=C4)OCCF

Molecular Formula

C27H28FN5O2

Molecular Weight

473.54

References & Citations

[1]Saito H, et al. Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain. Bioorg Med Chem Lett. 2024 Jan 20:129625.