PCSK9-IN-23
Product Specifications
UNSPSC Description
PCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression[1].
Target Antigen
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-23.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(NCC2=CC=C(C(F)(F)F)C=C2)C=C(C)N1CC3=CC=C(C(F)(F)F)C=C3
Molecular Weight
440.38
References & Citations
[1]Lisa Giannessi, et al. Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability. Eur J Med Chem. 2023 Dec 20:265:116063.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157434/PCSK9-IN-23-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157434/
Clinical Information
No Development Reported
CAS Number
2115700-96-2
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