EGFR T790M/L858R-IN-3
EGFR T790M/L858R-IN-3 (compound B1) is a EGFRL858R/T790M inhibitor with IC50 value of 13 nM. EGFR T790M/L858R-IN-3 shows anti-tumour activity in H1975 cells with an IC50 value of 0.087 μΜ. EGFR T790M/L858R-IN-3 inhibits cell migration in A549 cells and induces apoptosis in H1975 cells[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-t790m-l858r-in-3.html
Solubility
10 mM in DMSO
Smiles
C=C(C(NC1=CC(NC2=NC3=C(C(N4CCC5=C(C4)C=CS5)=N2)SC=C3)=C(C=C1N(CCN(C)C)C)OC)=O)Cl
Molecular Formula
C28H32ClN7O2S2
Molecular Weight
598.18
References & Citations
[1]Fu J, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFRL858R/T790M inhibitors. J Enzyme Inhib Med Chem. 2023;38 (1) :2205605.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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