HDAC6-IN-27
HDAC6-IN-27 (compound 8C) is a HDAC inhibitor with IC50 vales of 15.9 nM 136.5 nM and 6180.2 nM for HDAC6, HDAC8 and HDAC1, respectively. HDAC6-IN-27 shows potent antiparasitic effects[1].
Product Specifications
CAS Number
[2758023-91-3]
UNSPSC
12352005
Target
HDAC; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hdac6-in-27.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC(NC2=CC=C(OC)C=C2)=O)C=C1)NO
Molecular Formula
C15H15N3O4
Molecular Weight
301.30
References & Citations
[1]Maurício T Tavares, et al. 1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors. Sci Rep. 2023 Nov 29;13 (1) :21006.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6; HDAC8
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