C105SR
C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase) . C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC) . C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; Cyclophilin
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/c105sr.html
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC(NCC1=CC2=C(NCCC2)C=C1)=O)C3=CC(Br)=CC=C3OC)N4[C@@H](C5=C6C(C=CS6)=CC=C5)CCC4
Molecular Formula
C32H33BrN4O3S
Molecular Weight
633.60
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; Cyclophilin D
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