Cbl-b-IN-10

Cbl-b-IN-10 (Compound 463) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.0 nM and 3.5 nM, respectively[1].

Product Specifications

CAS Number

[2815225-12-6]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cbl-b-in-10.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(CNC3(CCC3)C)=CC(C(F)(F)F)=C2CN1C4=CC(NCC)=CC(C5(CCC5)CC6=NN=CN6C)=C4

Molecular Formula

C31H37F3N6O

Molecular Weight

566.66

References & Citations

[1]Jun Liang, et al. Lactams as cbl-b inhibitors. Patent WO2022169997A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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