RIPK1-IN-16

RIPK1-IN-16 is an orally active and potent inhibitor of RIPK1. RIPK1-IN-16 inhibits excessive inflammation by blocking RIPK1-mediated necroptosis in vivo. RIPK1-IN-16 protects mouse from TNF-induced systemic inflammatory response syndrome and sepsis[1].

Product Specifications

CAS Number

[2561431-77-2]

UNSPSC

12352005

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ripk1-in-16.html

Solubility

10 mM in DMSO

Smiles

CN1C2=CC=CC=C2OC[C@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)C1=S

Molecular Formula

C20H19N5O2S

Molecular Weight

393.46

References & Citations

[1]Ling ZY, et al. Protective Effect of a Novel RIPK1 Inhibitor, Compound 4-155, in Systemic Inflammatory Response Syndrome and Sepsis. Inflammation. 2023 Oct;46 (5) :1796-1809.