JNK-IN-14
JNK-IN-14 is a potent JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis. JNK-IN-14 shows cell population arrest at the G2/M phase and slightly inhibits beclin-1 production at K562 leukemia cells relative to SP600125 (HY-12041), showing higher inhibitory ability.[1]
Product Specifications
CAS Number
[2991432-56-3]
UNSPSC
12352005
Target
Cytochrome P450; JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnk-in-14.html
Solubility
10 mM in DMSO
Smiles
CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C
Molecular Formula
C27H31N5O4S
Molecular Weight
521.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2D6; CYP3A4; JNK1; JNK2; JNK3
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Neugrin, Neurite Outgrowth Associated (Neurite Outgrowth-associated Protein, NEUGRIN, NGRN, DSC92, Mesenchymal Stem Cell Protein DSC92, Spinal Cord-derived Protein FI58G) discontinued
