FD2157

FD2157 is a photosensitive PI3K inhibitor, with IC50s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fd2157.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC1=CC(OC)=C(OC)C=C1[N+]([O-])=O)N(N=C2)C(C2=C3)=NC=C3C4=CN=C(Cl)C(NS(=O)(C5=CC=CC=C5)=O)=C4

Molecular Formula

C27H21ClN6O8S

Molecular Weight

625.01

References & Citations

[1]Yang C, et al. Discovery of a photosensitizing PI3K inhibitor for tumor therapy: Design, synthesis and in vitro biological evaluation. Bioorg Med Chem Lett. 2023 Oct 1;94:129459.