ET receptor antagonist 2

ET receptor antagonist 2 (compound 16j) is an orally active ET receptor antagonist (IC50=0.22 nM), which can be used for research in pulmonary arterial hypertension (PAH) . ET receptor antagonist 2 attenuates monocrotaline (HY-N0750) induced PAH in rat model[1].

Product Specifications

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/et-receptor-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(NC1=NC(C2=NC=CC=N2)=NC(OCC/C=C/CC)=C1OC3=CC=CC=C3OC)=O

Molecular Formula

C22H25N5O5S

Molecular Weight

471.53

References & Citations

[1]Panchal J, et al. Development of novel bosentan analogues as endothelin receptor antagonists for pulmonary arterial hypertension. Eur J Med Chem. 2023 Nov 5;259:115681.