G43

G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study[1][2].

Product Specifications

CAS Number

[690693-02-8]

UNSPSC

12352005

Target

Bacterial; Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/g43.html

Purity

99.76

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(S1)C=CC([N+]([O-])=O)=C2)NC3=CC=CC=C3C(N)=O

Molecular Formula

C16H11N3O4S

Molecular Weight

341.34

References & Citations

[1]Zhang Q, et al. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci Rep. 2017;7 (1) :5974.|[2]Scaffa PMC, et al. The potential use of glycosyl-transferase inhibitors for targeted reduction of S. mutans biofilms in dental materials. Sci Rep. 2023;13 (1) :11889.