JPC0323

JPC0323 is a dual 5-HT2C/5-HT2A receptor positive allosteric modulator. JPC0323 has on-target properties, acceptable plasma exposure and brain penetration. JPC0323 can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[5972-45-2]

UNSPSC

12352211

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jpc0323.html

Purity

99.5

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

O=C(NC(CO)(CO)CO)CCCCCCC/C=C\CCCCCCCC

Molecular Formula

C22H43NO4

Molecular Weight

385.58

References & Citations

[1]Chen J, et al. Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators. J Med Chem. 2023 Jul 27;66 (14) :9992-10009.