GSPT1 degrader-1
GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system, serves as one of Molecular Glues. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gspt1-degrader-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(CN(C)CCOC)C=C(NC(CCC2=CC=C3CN(C4CCC(NC4=O)=O)C(C3=C2)=O)=O)C=C1Cl
Molecular Formula
C28H33ClN4O5
Molecular Weight
541.04
References & Citations
[1]Wei Y, et al. Discovery of new Lenalidomide derivatives as potent and selective GSPT1 degraders. Eur J Med Chem. 2023 Oct 5;258:115580.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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