Antileishmanial agent-19
Product Specifications
UNSPSC Description
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals[1].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antileishmanial-agent-19.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC=CC=C1)COC2=CC=C(C(N3C)=NC4=C(C=CC=C4)C3=O)C=C2
Molecular Weight
386.40
References & Citations
[1]Ansari A, et al. Discovery, SAR and mechanistic studies of quinazolinone-based acetamide derivatives in experimental visceral leishmaniasis. Eur J Med Chem. 2023 Sep 5;257:115524.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155520/Antileishmanial-agent-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155520/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
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