NKG2D-IN-1
Product Specifications
UNSPSC Description
NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.3 µM and 0.7 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively[1].
Target Antigen
C-type Lectin-like Receptor (CTLR)
Type
Reference compound
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nkg2d-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1N=CC=C1C2=CC(C(NC(C(N(C)C)=O)C3=CC=CC(C(F)(F)F)=C3)=O)=C(C4=CC=C(C(F)(F)F)C=C4)C=C2
Molecular Weight
574.52
References & Citations
[1]Jocelyn Wang, et al. Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D). Bioorg Med Chem Lett. 2023 Sep 29:129492.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155311/NKG2D-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155311/
Clinical Information
No Development Reported
Curated Selection
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