SARS-CoV-2-IN-60
Product Specifications
UNSPSC Description
SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics[1].
Target Antigen
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-in-60.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(/C=C/C2=NC(O)=NC(C(F)(F)F)=C2)C(Cl)=C1
Molecular Weight
335.11
References & Citations
[1]Nicole L Inniss, et al. Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors. ACS Infect Dis. 2023 Oct 13;9(10):1918-1931.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155280/SARS-CoV-2-IN-60-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155280/
Clinical Information
No Development Reported
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