CBP/p300-IN-21
Product Specifications
UNSPSC Description
CBP/p300-IN-21 (Compound 5d) is a selective CBP/p300 inhibitor (IC50: 0.07 and 1.755 μM for p300 and CBP). CBP/p300-IN-21 decreases H3K18Ac level. CBP/p300-IN-21 inhibits growth of 4T1 tumor growth in mice[1].
Target Antigen
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-21.html
Solubility
10 mM in DMSO
Smiles
OC(C(OC)=C1)=CC(C1=C2)=CC3=[N+]2CCC4=CC(OCO5)=C5C=C43.[Cl-]
Molecular Weight
357.79
References & Citations
[1]Zhong X, et al. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors. Bioorg Chem. 2023 Sep;138:106597.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155229/CBP-p300-IN-21-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155229/
Clinical Information
No Development Reported
CAS Number
1065581-69-2
Curated Selection
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