CBP/p300-IN-21
CBP/p300-IN-21 (Compound 5d) is a selective CBP/p300 inhibitor (IC50: 0.07 and 1.755 μM for p300 and CBP) . CBP/p300-IN-21 decreases H3K18Ac level. CBP/p300-IN-21 inhibits growth of 4T1 tumor growth in mice[1].
Product Specifications
CAS Number
[1065581-69-2]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-21.html
Solubility
10 mM in DMSO
Smiles
OC(C(OC)=C1)=CC(C1=C2)=CC3=[N+]2CCC4=CC(OCO5)=C5C=C43.[Cl-]
Molecular Formula
C19H16ClNO4
Molecular Weight
357.79
References & Citations
[1]Zhong X, et al. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors. Bioorg Chem. 2023 Sep;138:106597.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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