mTOR inhibitor-13
Product Specifications
UNSPSC Description
mTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].
Target Antigen
mTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-13.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=NC3=C(C(N4C[C@@H]5O[C@@H](CC5)C4)=N2)SC=C3)C=C1)NC6=CC=CN=C6
Molecular Weight
458.54
References & Citations
[1]Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155211/mTOR-inhibitor-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155211/
Clinical Information
No Development Reported
CAS Number
1144075-44-4
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