PROTAC Hsp90α degrader 1
Product Specifications
UNSPSC Description
PROTAC Hsp90α degrader 1 (Compound X10g) is a selective PROTAC Hsp90α degrader. PROTAC Hsp90α degrader 1 can be used for breast cancer research. PROTAC Hsp90α degrader 1 inhibits the proliferation of MDA-MB-231, MDA-MB-468, MCF-7, MX-1 cells with IC50s of 51.48 μM, 16.46 μM, 8.93 μM, 11.95 μM respectively[1].
Target Antigen
HSP; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-hsp90α-degrader-1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C(N2CC3=CC=C(CN4CCN(CCCCCCC(NC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CC4)C=C3C2)=O)C=C1C(C)C
Molecular Weight
762.89
References & Citations
[1]Jiang Q, et al. Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancer. Eur J Med Chem. 2023 Jul 28;260:115690.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155113/PROTAC-Hsp90α-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155113/
Clinical Information
No Development Reported
CAS Number
3031078-90-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS9425182-02 5x 96 Tests
Mouse Mast/stem cell growth factor receptor Kit ELISA Kit
Ask
View Details